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Article

p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget’s disease–like bone phenotypes in mice

19 Mar 2018

Abstract excerpt

The sequestosome 1 gene encodes the p62 protein and is the major genetic risk factor associated with Paget's disease of bone. In 2004, p62 was reported to up-regulate osteoclast differentiation by activating the transcription factors Nfatc1 and NF-κB. Here, we characterized the osteoclastogenic potential of murine p62 −/− -derived cells compared with WT cells. Our data confirmed previous findings indicating that...

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PMID: 29555685
DOI: 10.1074/jbc.ra118.002449

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p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget’s disease–like bone phenotypes in micePMID 29555685Read ↗

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