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Article

Sequential expression of phenotype markers for osteoclasts during differentiation of precursors for multinucleated cells formed in long-term human marrow cultures.

Endocrinology - 1 Dec 1990

Kurihara N, Gluck S, Roodman G D

Abstract excerpt

Long-term human marrow cultures form multi-nucleated cells (MNC) which express the osteoclast phenotype. Mononuclear precursors for these MNC can be identified and highly enriched. We tested early (bipotent) and late (unipotent) precursors of these MNC for expression of several osteoclast differentiation markers: 1) the osteoclast vitronectin receptor, identified by the 23c6 monoclonal antibody, 2) the...

Topics

Biomarkers
Bone Marrow Cells
Calcitonin
Cell Adhesion
Cell Differentiation
Cells, Cultured
Colony-Forming Units Assay
Humans
Osteoclasts
Phenotype
Proton-Translocating ATPases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Calcitonin

Receptors, Cell Surface

Receptors, Immunologic

Receptors, Vitronectin

Source

Identifiers

PMID: 1701138
DOI: 10.1210/endo-127-6-3215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1701138-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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