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Article

Common signalling pathways in macrophage and osteoclast multinucleation

1 Jun 2018

Abstract excerpt

Macrophage cell fusion and multinucleation are fundamental processes in the formation of multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the regulation of bone mass. However, this basic cell phenomenon is poorly understood despite its pathophysiological relevance. Granulomas containing multinucleated giant cells are seen in a wide variety of complex inflammatory disorders, as...

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PMID: 29871956
DOI: 10.1242/jcs.216267

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