Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.

Oncogene - 4 Apr 2013

Rybanska I, Ishaq O, Chou J, Prakash M, Bakhsheshian J, Huso D L, Franco S

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)/DNA-PKcs(-/-) (P1(-/-)/D(-/-)) mice. We found that, despite defective V(D)J recombination,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cesium Radioisotopes
Share to DNA-Activated Protein Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Lymphoma

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerases

Share to Radiation Tolerance

Share to Thymocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 22614020
DOI: 10.1038/onc.2012.199
PMCID: PMC4710090

Genes

PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.PMID 22614020Read ↗

Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in miceSemantic proximity Read ↗

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Semantic proximity Read ↗

Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.Semantic proximity Read ↗

Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.Semantic proximity Read ↗

DNA damage pathways and B-cell lymphomagenesis.Semantic proximity Read ↗

Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in miceSemantic proximity Read ↗

Poly (ADP-ribose) polymerase-1 deficiency does not affect ethylnitrosourea mutagenicity in liver and testis of lacZ transgenic mice.Semantic proximity Read ↗

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.Semantic proximity Read ↗

PARP1 is required for chromosomal translocationsSemantic proximity Read ↗

Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activationSemantic proximity Read ↗

Mechanisms of oncogenic chromosomal translocationsSemantic proximity Read ↗

Atm-deficient mice: a paradigm of ataxia telangiectasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.