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In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene.

Environmental and molecular mutagenesis - 1 May 2006

Hashimoto Akiko H, Amanuma Kimiko, Hiyoshi Kyoko, Takano Hirohisa, Masumura Ken-ichi, Nohmi Takehiko, Aoki Yasunobu

Abstract excerpt

1,6-Dinitropyrene (1,6-DNP) is a ubiquitous airborne pollutant found in diesel exhaust. In this study, mutagenesis was examined in the lungs of gpt-delta transgenic mice after intratracheal instillation of 0-0.1 mg 1,6-DNP. In addition, the 1,6-DNP-induced gpt mutation spectrum was compared with that of control mice. A single intratracheal injection of 0-0.05 mg 1,6-DNP resulted in significant dose-dependent...

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PMID: 16489625
DOI: 10.1002/em.20204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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