Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice.

Cancer research - 15 Jun 2007

Aoki Yasunobu, Hashimoto Akiko H, Amanuma Kimiko, Matsumoto Michi, Hiyoshi Kyoko, Takano Hirohisa, Masumura Ken-ichi, Itoh Ken, Nohmi Takehiko, Yamamoto Masayuki

Abstract excerpt

The lung is an organ that is sensitive to mutations induced by chemicals in ambient air, and transgenic mice harboring guanine phosphoribosyltransferase (gpt) gene as a target gene are a well-established model system for assessing genotoxicity in vivo. Transcription factor Nrf2 mediates inducible and constitutive expression of cytoprotective enzymes against xenobiotics and mutagens. To address whether Nrf2 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzo(a)pyrene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Immunoblotting

Share to Mutagenicity Tests

Share to NF-E2-Related Factor 2

Share to Testis

Source

Identifiers

PMID: 17575130
DOI: 10.1158/0008-5472.CAN-06-3355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice.PMID 17575130Read ↗

In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice.Semantic proximity Read ↗

Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust.Semantic proximity Read ↗

Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate.Semantic proximity Read ↗

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.Semantic proximity Read ↗

Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice.Semantic proximity Read ↗

Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels.Semantic proximity Read ↗

In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene.Semantic proximity Read ↗

Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.Semantic proximity Read ↗

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.Semantic proximity Read ↗

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis.Semantic proximity Read ↗

In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.Semantic proximity Read ↗

Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.