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Increase in mutation frequency in lung of Big Blue rat by exposure to diesel exhaust.

Carcinogenesis - 1 Apr 2000

Sato H, Sone H, Sagai M, Suzuki K T, Aoki Y

Abstract excerpt

Exposure to diesel exhaust (DE) is known to cause lung tumors in rats. To clarify the mutagenicity of DE, we estimated mutant frequency (MF) and determined the mutation spectra in rat lung after exposure to DE using lambda/lacI transgenic rats (Big Blue system). Male Big Blue rats (6 weeks old) were exposed for 4 weeks to 1 or 6 mg/m(3) DE, which contains suspended particulate matter. Control rats were maintained...

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Identifiers

PMID: 10753200
DOI: 10.1093/carcin/21.4.653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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