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Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust.

Environmental and molecular mutagenesis - 1 Oct 2007

Hashimoto Akiko H, Amanuma Kimiko, Hiyoshi Kyoko, Sugawara Yoshiki, Goto Sataro, Yanagisawa Rie, Takano Hirohisa, Masumura Ken-ichi, Nohmi Takehiko, Aoki Yasunobu

Abstract excerpt

Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In the lungs of mice treated with inhalation of 3 mg m(-3) DE for 12 weeks, the mutant frequency (MF)...

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Source

Identifiers

PMID: 17896790
DOI: 10.1002/em.20335

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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