Article
Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation.
Oncogene - 1 Jun 1991
Marcellus R, Whitfield J F, Raptis L
Abstract excerpt
Twelve independent rat F111 cell lines expressing the polyoma virus middle tumor antigen (mT) under control of the dexamethasone-regulatable MMTV-LTR promoter were assayed for levels of membrane-associated protein kinase C (PKC) activity. Low background levels of mT antigen expression (approximately 2%), although insufficient for transformation, triggered a dramatic increase in PKC activity. Under the same...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Cell Line, Transformed
- Cell Membrane
- Cell Transformation, Neoplastic
- Enzyme Activation
- Membrane Proteins
- Oncogene Protein pp60(v-src)