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Article

Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.

American journal of physiology. Cell physiology - 1 May 2011

Best Jabe M, Foell Jason D, Buss Courtney R, Delisle Brian P, Balijepalli Ravi C, January Craig T, Kamp Timothy J

Abstract excerpt

L-type Ca(2+) channels (LTCCs) play a critical role in Ca(2+)-dependent signaling processes in a variety of cell types. The number of functional LTCCs at the plasma membrane strongly influences the strength and duration of Ca(2+) signals. Recent studies demonstrated that endosomal trafficking provides a mechanism for dynamic changes in LTCC surface membrane density. The purpose of the current study was to...

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Identifiers

PMID: 21248079
DOI: 10.1152/ajpcell.00288.2010
PMCID: PMC3093944

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