Article
Rab11 regulates the recycling of the beta2-adrenergic receptor through a direct interaction.
The Biochemical journal - 15 Feb 2009
Parent Audrey, Hamelin Emilie, Germain Pascale, Parent Jean-Luc
Abstract excerpt
The beta2ARs (beta(2)-adrenergic receptors) undergo ligand-induced internalization into early endosomes, but then are rapidly and efficiently recycled back to the plasma membrane, restoring the numbers of functional cell-surface receptors. Gathering evidence suggests that, during prolonged exposure to agonist, some beta2ARs also utilize a slow recycling pathway through the perinuclear recycling endosomal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.