Article
Unexpected diversity of signal peptides in prokaryotes.
mBio - 20 Nov 2012
Payne Samuel H, Bonissone Stefano, Wu Si, Brown Roslyn N, Ivankov Dmitry N, Frishman Dmitrij, Pasa-Tolić Ljiljana, Smith Richard D, Pevzner Pavel A
Abstract excerpt
UNLABELLED: Signal peptides are a cornerstone mechanism for cellular protein localization, yet until now experimental determination of signal peptides has come from only a narrow taxonomic sampling. As a result, the dominant view is that Sec-cleaved signal peptides in prokaryotes are defined by a canonical AxA motif. Although other residues are permitted in the motif, alanine is by far the most common. Here we...
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