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Article

Propeptide engineering of Aspergillus niger-derived aspartic protease PepA for enhanced catalytic activity.

International journal of biological macromolecules - 1 Jan 2026

Zhang Anrong, Chang Chenghe, Fan Bingbing, Wu Zhenlong, Yang Ying

Abstract excerpt

The propeptide of aspartic proteases plays a critical role in correct folding and functional maturation, yet its precise regulatory mechanism remains to be fully elucidated. This study systematically investigated the structure-function relationship of the propeptide in Aspergillus niger-derived aspartic protease PepA via propeptide engineering. We found that an intact propeptide structure is indispensable for...

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PMID: 41500273
DOI: 10.1016/j.ijbiomac.2026.150116

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