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Article

Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition.

Proteins - 1 Sept 2018

Bjerga Gro E K, Larsen Øivind, Arsın Hasan, Williamson Adele, García-Moyano Antonio, Leiros Ingar, Puntervoll Pål

Abstract excerpt

Intracellular subtilisin proteases (ISPs) have important roles in protein processing during the stationary phase in bacteria. Their unregulated protein degrading activity may have adverse effects inside a cell, but little is known about their regulatory mechanism. Until now, ISPs have mostly been described from Bacillus species, with structural data from a single homolog. Here, we study a marine ISP originating...

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Identifiers

PMID: 29907987
DOI: 10.1002/prot.25528
PMCID: PMC6220982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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