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Article

Repositioning of the reaction intermediate within the catalytic center of the spliceosome.

Molecular cell - 17 Feb 2006

Konarska Maria M, Vilardell Josep, Query Charles C

Abstract excerpt

Conformational change within the spliceosome is required between the first catalytic step of pre-mRNA splicing, when the branch site attacks the 5' splice site (SS), and the second step, when the 5' exon attacks the 3'SS. Little is known, however, about repositioning of the reaction substrates during this transition. Whereas the 5'SS is positioned for the first step by pairing with the invariant U6 snRNA-ACAGAG...

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Identifiers

PMID: 16483935
DOI: 10.1016/j.molcel.2006.01.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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