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Article

Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA.

The Journal of biological chemistry - 3 Nov 2006

Mero Patricia, Zhang Christine Y, Huang Zhen-Yu, Kim Moo-Kyung, Schreiber Alan D, Grinstein Sergio, Booth James W

Abstract excerpt

Endocytosis of the Fc receptor Fc gammaRIIA depends on a functional ubiquitin conjugation system, and the receptor becomes ubiquitylated upon ligand binding. Phosphorylation of tyrosines in Fc gammaRIIA by Src family kinases is thought to be the initiating event in its signaling. However, although the Src family kinase inhibitor PP1 inhibited both ligand-induced phosphorylation of Fc gammaRIIA and phagocytosis in...

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Identifiers

PMID: 16959774
DOI: 10.1074/jbc.M605372200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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