Article
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Scheffner M, Münger K, Byrne J C, Howley P M
Abstract excerpt
Human cervical carcinoma cell lines that were either positive or negative for human papillomavirus (HPV) DNA sequences were analyzed for evidence of mutation of the p53 and retinoblastoma genes. Each of five HPV-positive cervical cancer cell lines expressed normal pRB and low levels of wild-type...
Topics
- Base Sequence
- Blotting, Western
- Carcinoma
- DNA, Neoplasm
- Female
- Genes
- Genes, Retinoblastoma
- Humans
- Keratinocytes
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Papillomaviridae
- Polymerase Chain Reaction
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- Uterine Cervical Neoplasms