Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines.

doi:10.1002/mc.2940040302

Back to search

Article

Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines.

Molecular carcinogenesis - 1 Jan 1991

Wrede D, Tidy J A, Crook T, Lane D, Vousden K H

Abstract excerpt

Mutations within the tumor suppressor genes Rb-1 and p53 are commonly found in many human malignancies, and loss of wild-type function of both p53 and RB appear to be important events in the development of these malignancies. Interference with normal RB and p53 function in the cell has apparently...

Topics

Carcinoma
Cell Line
Female
Humans
Neoplasm Proteins
Papillomaviridae
Phenotype
Retinoblastoma Protein
Suppression, Genetic
Tumor Suppressor Protein p53
Tumor Virus Infections
Uterine Cervical Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.