Article
Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines.
Molecular carcinogenesis - 1 Jan 1991
Wrede D, Tidy J A, Crook T, Lane D, Vousden K H
Abstract excerpt
Mutations within the tumor suppressor genes Rb-1 and p53 are commonly found in many human malignancies, and loss of wild-type function of both p53 and RB appear to be important events in the development of these malignancies. Interference with normal RB and p53 function in the cell has apparently also been exploited by the oncogenic genital human papillomaviruses (HPVs), which encode transforming proteins capable...
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