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Article

Strain differences in the gating-disruptive effects of apomorphine: relationship to gene expression in nucleus accumbens signaling pathways.

Biological psychiatry - 15 Apr 2008

Shilling Paul D, Saint Marie Richard L, Shoemaker Jody M, Swerdlow Neal R

Abstract excerpt

BACKGROUND: Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is deficient in certain psychiatric disorders, including schizophrenia. Sprague Dawley (SD) rats are more sensitive to PPI-disruptive effects of apomorphine (APO) at long interstimulus intervals (ISIs) (60-120 msec) and less sensitive to PPI-enhancing effects of APO at short ISIs (10-30 msec) compared with Long Evans (LE)...

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Identifiers

PMID: 18083141
DOI: 10.1016/j.biopsych.2007.10.015
PMCID: PMC2771724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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