Article
Increased gene copy number of the transcription factor E2F1 in malignant melanoma.
Cancer biology & therapy - 1 Apr 2006
Nelson Mark A, Reynolds Steven H, Rao Uma N M, Goulet Anne-Christine, Feng Yongmei, Beas Anthony, Honchak Barbara, Averill Jim, Lowry David T, Senft Jamie R, Jefferson Amy M, Johnson Robert C, Sargent Linda M
Abstract excerpt
Translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process. We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11. Increased expression of E2F has been associated with the autonomous growth of melanoma cells, however, the molecular basis has...
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