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Article

Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells

20 Mar 2000

Abstract excerpt

Inactivation of the retinoblastoma tumor suppressor protein (pRb) has been implicated in melanoma cells, but the molecular basis for this phenotype has not yet been elucidated, and the status of additional family members (p107 and p130, together termed pocket proteins) or the consequences on downstream targets such as E2F transcription factors are not known. Because cell cycle progression is dependent on the...

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PMID: 10727462
DOI: 10.1084/jem.191.6.1005

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