Article
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.
Cancer cell - 1 Dec 2004
Du Jinyan, Widlund Hans R, Horstmann Martin A, Ramaswamy Sridhar, Ross Ken, Huber Wade E, Nishimura Emi K, Golub Todd R, Fisher David E
Abstract excerpt
The genomic organization of the CDK2 gene, which overlaps the melanocyte-specific gene SILV/PMEL17, poses an interesting regulatory challenge. We show that, despite its ubiquitous expression, CDK2 exhibits tissue-specific regulation by the essential melanocyte lineage transcription factor MITF. In addition, functional studies revealed this regulation to be critical for maintaining CDK2 kinase activity and growth...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.