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<i>DDEF1</i> Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma

15 May 2005

Abstract excerpt

PURPOSE: The molecular pathogenesis of uveal melanoma is poorly understood but is usually accompanied by amplification of chromosome 8q, suggesting the activation of one or more oncogenes. We recently identified a gene expression profile that distinguishes low-grade from high-grade melanomas. In this profile, a cluster of genes at chromosome 8q was overexpressed in high-grade tumors, providing an opportunity to...

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PMID: 15897555
DOI: 10.1158/1078-0432.ccr-04-1941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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