Article
The role of BPTF in melanoma progression and in response to BRAF-targeted therapy.
Journal of the National Cancer Institute - 23 Feb 2015
Dar Altaf A, Nosrati Mehdi, Bezrookove Vladimir, de Semir David, Majid Shahana, Thummala Suresh, Sun Vera, Tong Schuyler, Leong Stanley P L, Minor David, Billings Paul R, Soroceanu Liliana, Debs Robert, Miller James R, Sagebiel Richard W, Kashani-Sabet Mohammed
Abstract excerpt
BACKGROUND: Bromodomain PHD finger transcription factor (BPTF) plays an important role in chromatin remodeling, but its functional role in tumor progression is incompletely understood. Here we explore the oncogenic effects of BPTF in melanoma. METHODS: The consequences of differential expression of BPTF were explored using shRNA-mediated knockdown in several melanoma cell lines. Immunoblotting was used to assess...
Topics
Join the communities discussing this publication.