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Article

E2F1 in Melanoma Progression and Metastasis

22 Dec 2009

Abstract excerpt

Metastases are responsible for cancer deaths, but the molecular alterations leading to tumor progression are unclear. Overexpression of the E2F1 transcription factor is common in high-grade tumors that are associated with poor patient survival. To investigate the association of enhanced E2F1 activity with aggressive phenotype, we performed a gene-specific silencing approach in a metastatic melanoma model....

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PMID: 20026813
DOI: 10.1093/jnci/djp458

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