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Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?

7 Aug 2014

Abstract excerpt

Classically, as a transcription factor family, the E2Fs are known to regulate the expression of various genes whose products are involved in a multitude of biological functions, many of which are deregulated in diseases including cancers. E2F is deregulated and hyperactive in most human cancers with context dependent, dichotomous and contradictory roles in almost all cancers. Cancer cells have an insatiable...

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PMID: 25101673
DOI: 10.1038/cddis.2014.326

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