Article
Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
The Biochemical journal - 1 Feb 2006
Wingate Andrew D, Campbell David G, Peggie Mark, Arthur J Simon C
Abstract excerpt
Nur77 is a nuclear orphan receptor that is able to activate transcription independently of exogenous ligand, and has also been shown to promote apoptosis on its localization to mitochondria. Phosphorylation of Nur77 on Ser354 has been suggested to reduce ability of Nur77 to bind DNA; however, the kinase responsible for this phosphorylation in cells has not been clearly established. In the present study, we show...
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