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Article

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function.

Human genetics - 1 May 2006

He Jian-Qing, Burkett Kelly, Connett John E, Anthonisen Nicholas R, Paré Peter D, Sandford Andrew J

Abstract excerpt

Interactions between genetic and environmental determinants are likely to be important in the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that interferon gamma (IFNG) single nucleotide polymorphisms (SNPs) and their interaction with smoking are associated with the rate of decline or level of lung function in smokers. We studied four SNPs in IFNG in 585 non-Hispanic whites (NHW) who had...

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Source

Identifiers

PMID: 16474934
DOI: 10.1007/s00439-006-0143-z

Genes

IFNG
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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