Article
Associations of IL6 polymorphisms with lung function decline and COPD.
Thorax - 1 Aug 2009
He J-Q, Foreman M G, Shumansky K, Zhang X, Akhabir L, Sin D D, Man S F P, DeMeo D L, Litonjua A A, Silverman E K, Connett J E, Anthonisen N R, Wise R A, Paré P D, Sandford A J
Abstract excerpt
BACKGROUND: Interleukin-6 (IL6) is a pleiotropic pro-inflammatory and immunomodulatory cytokine which probably plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers....
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