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Article

Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers.

Respiratory medicine - 1 May 2007

Ogawa Emiko, Ruan Jian, Connett John E, Anthonisen Nicholas R, Paré Peter D, Sandford Andrew J

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation in the airways, parenchyma and vessels, which can cause a structural remodeling with increased fibrosis that narrows and fixes the airway lumen. Transforming growth factor-beta1 (TGF-beta1), a multifunctional growth factor, was reported to be increased in the airways of COPD patients. In this study, we hypothesized that...

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PMID: 17071067
DOI: 10.1016/j.rmed.2006.09.008

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FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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