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Article

IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

BMC pulmonary medicine - 21 Mar 2018

Egli Adrian, Mandal Jyotshna, Schumann Desiree M, Roth Michael, Thomas Brad, Lorne Tyrrell D, Blasi Francesco, Kostikas Kostantinos, Boersma Wim, Milenkovic Branislava, Lacoma Alicia, Rentsch Katharina, Rohde Gernot G U, Louis Renaud, Aerts Joachim G, Welte Tobias, Torres Antoni, Tamm Michael, Stolz Daiana

Abstract excerpt

BACKGROUND: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? METHODS: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of...

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Source

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Identifiers

PMID: 29562888
DOI: 10.1186/s12890-018-0616-6
PMCID: PMC5861655

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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