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Article

Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.

Respiratory research - 15 May 2006

Wallace Alison M, He Jian-Qing, Burkett Kelly M, Ruan Jian, Connett John E, Anthonisen Nicholas R, Paré Peter D, Sandford Andrew J

Abstract excerpt

BACKGROUND: Alpha-defensins, which are major constituents of neutrophil azurophilic granules, and beta-defensins, which are expressed in airway epithelial cells, could contribute to the pathogenesis of chronic obstructive pulmonary disease by amplifying cigarette smoke-induced and infection-induced inflammatory reactions leading to lung injury. In Japanese and Chinese populations, two different beta-defensin-1...

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Identifiers

PMID: 16700921
DOI: 10.1186/1465-9921-7-76
PMCID: PMC1523340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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