Article
Glutathione S-transferase variants and their interaction with smoking on lung function.
American journal of respiratory and critical care medicine - 15 Aug 2004
He Jian-Qing, Connett John E, Anthonisen Nicholas R, Paré Peter D, Sandford Andrew J
Abstract excerpt
We studied glutathione S-transferase (GST) polymorphisms in 1,098 whites with the lowest (n = 544, FEV(1) % predicted mean +/- SEM = 62.6 +/- 0.1) and the highest (n = 554, FEV(1) % predicted mean +/- SEM = 91.8 +/- 0.1) lung function at the beginning of the Lung Health Study. Homozygosity for GSTP1 105Val was significantly more frequent in the low- than in the high-function group (13.2 vs. 9.3%) (odds ratio =...
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