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Article

Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.

Thorax - 1 Nov 2001

Joos L, McIntyre L, Ruan J, Connett J E, Anthonisen N R, Weir T D, Paré P D, Sandford A J

Abstract excerpt

BACKGROUND: There is increasing evidence that the cytokine network is central to the immunopathology of inflammatory airway diseases. The interleukin 1 (IL-1) receptor antagonist (IL-1RN) is a naturally occurring anti-inflammatory agent that binds to the IL-1 receptor but does not possess agonist activity. Each of the genes of the IL-1 locus on chromosome 2q14 is polymorphic. The IL1RN gene contains an 86 bp...

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Identifiers

PMID: 11641511
DOI: 10.1136/thorax.56.11.863
PMCID: PMC1745962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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