Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility genes for rapid decline of lung function in the lung health study.

American journal of respiratory and critical care medicine - 1 Feb 2001

Sandford A J, Chagani T, Weir T D, Connett J E, Anthonisen N R, Paré P D

Abstract excerpt

The genes that contribute to the genetic susceptibility to chronic obstructive pulmonary disease (COPD) remain largely unknown. We hypothesized that widely divergent rates of decline in lung function in smokers would be a robust phenotype for detection of genes that contribute to COPD severity. We selected 283 rapid decliners (deltaFEV1 = -154 +/- 3 ml/yr) and 308 nondecliners (deltaFEV1 = +15 +/- 2 ml/yr) from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epoxide Hydrolases
Share to Forced Expiratory Volume

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Lung Diseases, Obstructive

Share to Lymphotoxin-alpha

Share to Smoking

Share to Tumor Necrosis Factor-alpha

Share to Vitamin D-Binding Protein

Source

Identifiers

PMID: 11179124
DOI: 10.1164/ajrccm.163.2.2006158

Genes

TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility genes for rapid decline of lung function in the lung health study.PMID 11179124Read ↗

Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers.Semantic proximity Read ↗

Genetic predisposition to accelerated decline of lung function in COPD.Semantic proximity Read ↗

Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers.Semantic proximity Read ↗

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.Semantic proximity Read ↗

Association of lung function decline with the heme oxygenase-1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), FranceSemantic proximity Read ↗

The role of matrix metalloproteinase polymorphisms in the rate of decline in lung functionSemantic proximity Read ↗

Interferon gamma polymorphisms and their interaction with smoking are associated with lung function.Semantic proximity Read ↗

MMP12, lung function, and COPD in high-risk populations.Semantic proximity Read ↗

Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.Semantic proximity Read ↗

Genetic and Epigenetic Associations with Pre–Chronic Obstructive Pulmonary Disease Lung Function TrajectoriesSemantic proximity Read ↗

Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease.Semantic proximity Read ↗

Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.