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Article

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

13 Apr 2018

Abstract excerpt

Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1 -/∆ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1 -/∆ mice accumulated...

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Identifiers

PMID: 29747066
DOI: 10.1016/j.redox.2018.04.007

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