Article
p53 point mutation in HPV negative human cervical carcinoma cell lines.
Oncogene - 1 May 1991
Crook T, Wrede D, Vousden K H
Abstract excerpt
Clinical and experimental evidence is consistent with a key role for transforming human papilloma viruses (HPVs) in the aetiology of anogenital carcinoma. Cervical carcinoma does, however, occasionally occur in the absence of HPV sequences (Riou et al., 1990). We have used a direct cDNA/PCR sequencing protocol to analyse the sequence of p53 mRNA expressed by HPV positive and negative cervical carcinoma cell...
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