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Article

Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii.

PLoS pathogens - 1 Dec 2025

Perrier Anthony, Budin-Verneuil Aurélie, Hallez Régis

Abstract excerpt

The (p)ppGpp-dependent stress response is required for pathogenic bacteria to survive both outside and inside the host but the mechanisms behind this survival are mostly unknown. In this study, we characterize the (p)ppGpp metabolism in the opportunistic pathogen multi-drug-resistant Acinetobacter baumannii. We show that two stressful conditions potentially encountered during infection - iron starvation and...

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Identifiers

PMID: 41411374
DOI: 10.1371/journal.ppat.1013795
PMCID: PMC12742793

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