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Article

Guanosine 3'-diphosphate 5'-diphosphate is not required for growth rate-dependent control of rRNA synthesis in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990

Gaal T, Gourse R L

Abstract excerpt

rRNA synthesis in Escherichia coli is subject to at least two regulation systems, growth rate-dependent control and stringent control. The inverse correlation between rRNA synthesis rates and guanosine 3'-diphosphate 5'-diphosphate (ppGpp) levels under various physiological conditions has led to the supposition that ppGpp is the mediator of both control mechanisms by inhibiting transcription from rrn P1...

Topics

Cloning, Molecular
Escherichia coli
Genes, Bacterial
Genotype
Guanine Nucleotides
Guanosine Tetraphosphate
Kinetics
Mutation
Plasmids
Promoter Regions, Genetic
RNA, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2196571
DOI: 10.1073/pnas.87.14.5533
PMCID: PMC54359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2196571-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Guanosine 3'-diphosphate 5'-diphosphate is not required for growth rate-dependent control of rRNA synthesis in Escherichia coli.PMID 2196571Read ↗

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