Article
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2006
Schleypen Julia S, Baur Nicole, Kammerer Robert, Nelson Peter J, Rohrmann Karl, Gröne Elisabeth F, Hohenfellner Markus, Haferkamp Axel, Pohla Heike, Schendel Dolores J, Falk Christine S, Noessner Elfriede
Abstract excerpt
PURPOSE: Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renal cell carcinoma. EXPERIMENTAL DESIGN: Tumor-infiltrating lymphocytes (TIL) were isolated from renal cell carcinoma and analyzed for NK cell frequency and phenotype (n = 34). NK cells were enriched and tested for...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
- Cell Count
- Cell Line
- Cytotoxins
- Female
- Gene Expression Regulation, Neoplastic
- Granzymes