Article
KLRF1, a novel marker of CD56bright NK cells, predicts improved survival for patients with locally advanced bladder cancer.
Cancer medicine - 1 Apr 2023
Mukherjee Neelam, Ji Niannian, Tan Xi, Chen Chun-Liang, Noel Onika D V, Rodriguez-Padron Maria, Lin Chun-Lin, Alonzo David G, Huang Tim H, Svatek Robert S
Abstract excerpt
BACKGROUND: Bladder tumor-infiltrating CD56bright NK cells are more tumor cytotoxic than their CD56dim counterparts. Identification of NK cell subsets is labor-intensive and has limited utility in the clinical setting. Here, we sought to identify a surrogate marker of bladder CD56bright NK cells and to test its prognostic significance. METHODS: CD56bright and CD56dim NK cells were characterized with the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.