Article

Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancer

2022-02-08

Abstract excerpt

<title>Abstract</title> <p>NK cells are the predominant innate lymphocyte subset that contribute to anti-tumor immunity. The molecular profile of human tumor-infiltrating NK cells, and particularly, their characteristics in relation to CD8<sup>+</sup> cytotoxic T lymphocyte (CTL) density within tumors is poorly understood. Here, we performed single-cell and bulk transcriptomic analysis of NK cells within tumor an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30a50f4b-072d-55e3-87df-4c23d3110549
DOI: 10.21203/rs.3.rs-1294352/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancerDOI 10.21203/rs.3.rs-1294352/v1Read

Identification and Validation of a Novel Signature Based on NK Cell Marker Genes to Predict Prognosis and Immunotherapy Response in Lung Adenocarcinoma by Integrated Analysis of Single-Cell and Bulk RNA-SequencingSemantic proximity Read

Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancerSemantic proximity Read

Comparing NKp44+ and NKp44− ILC3s in Human Lung Cancer via Transcriptional SequencingSemantic proximity Read

Single-cell and spatial landscapes reveal coordinated CD8+ T-cell programs defining responder-specific immune niches in NSCLCSemantic proximity Read

Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune responseSemantic proximity Read

Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencingSemantic proximity Read

In-depth analysis of the interplay between oncogenic mutations and NK cell-mediated cancer surveillance in solid tumors.Semantic proximity Read

CD16a<sup>high</sup> NK cell infiltration and spatial relationships with T cells and macrophages can predict improved progression-free survival in high grade ovarian cancerSemantic proximity Read

Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligationSemantic proximity Read

Natural killer cell‑based immunotherapy for lung cancer: Challenges and perspectives (Review)Semantic proximity Read

Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcomeSemantic proximity Read

Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applicationsSemantic proximity Read