Article
Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers.
EBioMedicine - 1 Oct 2015
Krzywinska Ewelina, Allende-Vega Nerea, Cornillon Amelie, Vo Dang-Nghiem, Cayrefourcq Laure, Panabieres Catherine, Vilches Carlos, Déchanet-Merville Julie, Hicheri Yosr, Rossi Jean-François, Cartron Guillaume, Villalba Martin
Abstract excerpt
Natural killer (NK) cells, a cytotoxic lymphocyte lineage, are able to kill tumor cells in vitro and in mouse models. However, whether these cells display an anti-tumor activity in cancer patients has not been demonstrated. Here we have addressed this issue in patients with several hematological cancers. We found a population of highly activated CD56(dim)CD16(+) NK cells that have recently degranulated, evidence...
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