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Article

CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets.

Leukemia - 1 May 2005

Penack O, Gentilini C, Fischer L, Asemissen A M, Scheibenbogen C, Thiel E, Uharek L

Abstract excerpt

The activation of natural killer (NK) cells leads to degranulation and secretion of cytotoxic granula. During this process, the lytic granule membrane protein CD107a becomes detectable at the cell surface. Based on this phenomenon, we have analyzed by a novel flow cytometry-based assay, the number and phenotype of NK cells responding to tumor targets. Using human leukemia and lymphoma cell lines, we observed a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15744340
DOI: 10.1038/sj.leu.2403704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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