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Article

Diagnosis of preclinical scrapie in live sheep by the immunohistochemical examination of rectal biopsies.

The Veterinary record - 29 Mar 2008

González L, Dagleish M P, Martin S, Dexter G, Steele P, Finlayson J, Jeffrey M

Abstract excerpt

In most sheep infected with a transmissible spongiform encephalopathy (tse) the disease-associated prion protein (PrP(d)) accumulates in tissues of the lymphoreticular system, suggesting that it might be detected in biopsy specimens. A procedure has been developed to obtain biopsy specimens of rectal mucosa in which PrP(d) has been detected by immunohistochemistry in preclinically infected sheep of all...

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PMID: 18375983
DOI: 10.1136/vr.162.13.397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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