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Article

Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes.

Veterinary pathology - 1 May 2005

Ersdal C, Ulvund M J, Espenes A, Benestad S L, Sarradin P, Landsverk T

Abstract excerpt

Twenty-one orally inoculated and seven naturally infected sheep with scrapie were examined for PrP(Sc) in peripheral tissues and in the central nervous system (CNS), using immunohistochemistry. In the inoculated group, VRQ (valine at codon 136, arginine at codon 154 and glutamine at codon 171)/VRQ sheep generally had a greater accumulation of the pathologic form of prion protein (PrP(Sc)) in peripheral tissues,...

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PMID: 15872372
DOI: 10.1354/vp.42-3-258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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