Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1).

The Journal of general virology - 1 May 2002

Houston E F, Halliday S I, Jeffrey M, Goldmann W, Hunter N

Abstract excerpt

Scrapie does not occur in New Zealand (NZ), although PrP gene alleles associated with susceptibility to the disease are found at relatively high frequencies in NZ sheep. The hypothesis that scrapie is a genetic disease of sheep is thus unlikely to be true. To confirm that NZ sheep are actually susceptible to scrapie infection, NZ sheep of various PrP genotypes were challenged by subcutaneous inoculation with a...

Topics

Animals
Disease Susceptibility
Genotype
Immunohistochemistry
Prions
Scrapie
Sheep

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11961280
DOI: 10.1099/0022-1317-83-5-1247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1).PMID 11961280Read ↗

Scrapie-free Merino and Poll Dorset sheep from Australia and New Zealand have normal frequencies of scrapie-susceptible PrP genotypes.Semantic proximity Read ↗

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie.Semantic proximity Read ↗

The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks.Semantic proximity Read ↗

Scrapie.Semantic proximity Read ↗

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.Semantic proximity Read ↗

Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie.Semantic proximity Read ↗

Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland.Semantic proximity Read ↗

PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie.Semantic proximity Read ↗

Detection of PrP(Sc) in rectal biopsy and necropsy samples from sheep with experimental scrapie.Semantic proximity Read ↗

Risk of scrapie in British sheep of different prion protein genotype.Semantic proximity Read ↗

PrP genotype contributes to determining survival times of sheep with natural scrapie.Semantic proximity Read ↗

Pathogenesis, detection, and control of scrapie in sheep.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.