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Article

Pathophysiology of articular chondrocalcinosis--role of ANKH.

Nature reviews. Rheumatology - 1 Feb 2011

Abhishek Abhishek, Doherty Michael

Abstract excerpt

Calcium pyrophosphate (CPP) crystal deposition (CPPD) is associated with ageing and osteoarthritis, and with uncommon disorders such as hyperparathyroidism, hypomagnesemia, hemochromatosis and hypophosphatasia. Elevated levels of synovial fluid pyrophosphate promote CPP crystal formation. This extracellular pyrophosphate originates either from the breakdown of nucleotide triphosphates by plasma-cell membrane...

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Identifiers

PMID: 21102543
DOI: 10.1038/nrrheum.2010.182

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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