Article
Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli.
Immunology - 1 Apr 2008
Kullberg Bart Jan, Ferwerda Gerben, de Jong Dirk J, Drenth Joost P H, Joosten Leo A B, Van der Meer Jos W M, Netea Mihai G
Abstract excerpt
Mutations in nucleotide-binding oligomerization domain-2 (NOD2), leading to defective recognition of bacterial peptidoglycans, are associated with Crohn's disease. The underlying mechanism that results in increased inflammation in the guts of the patients bearing NOD2 mutations is still unclear. We hypothesized that NOD2 engagement leads to cross-tolerance to stimulation of Toll-like receptors (TLR), and we...
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