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Article

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Science (New York, N.Y.) - 21 Jun 2002

Dunah Anthone W, Jeong Hyunkyung, Griffin April, Kim Yong-Man, Standaert David G, Hersch Steven M, Mouradian M Maral, Young Anne B, Tanese Naoko, Krainc Dimitri

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis. Here, we report that huntingtin interacts with the transcriptional activator Sp1 and coactivator TAFII130. Coexpression of Sp1 and TAFII130 in cultured striatal cells from wild-type and HD transgenic mice...

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Identifiers

PMID: 11988536
DOI: 10.1126/science.1072613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.PMID 11988536Read ↗

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